Cancer treatments have been changed through the last 3 decades and include surgery, chemotherapy, and radiotherapy. Oral complications are commonly experienced by patients undergoing cancer therapy.
Mucositis, for example is one of the undesirable complications of radiotherapy which can ulcerate oral mucosa causing severe pain and discomfort which can affect oral normal function.
Green Propolis is a natural source of flavonoid which has anti-ulcer, antibacterial, anti-fungal, healing and anti-inflammatory effects. Using such an affordable compound without any bad smell or taste can help the radiotherapy undergoing patients. (2)
A study published in 2015 by a group os researchers, doctors and dentists, show that a group of patients selected to swish and swallow water based propolis extract had significantly lower grade of mucositis in all of the follow-ups, when compared with the group that did not take the propolis solution (1)
Another research mentions that the use of natural substances such as propolis aims to search for chemo prevention with fewer side effects. Desirable effects of propolis on the treatment of oral cancer are regression of tumors by stimulating multicellular immunity, prevention of metastasis, speeding up apoptosis of cancer cells, mitosis-suppressing effect, anti-angiogenesis effect, immunomodulatory effect, and antioxidant effect. Propolis maintains high circulating levels of chemotherapeutic drugs such as 5-FU and MMC, thus reducing the dose of these drugs. When concurrently administered with propolis, the dose and side effects of these chemotherapeutic drugs are reduced; the cytopenia resulting from these drugs is ameliorated by administration of propolis via increasing WBC and RBC counts in peripheral blood. Propolis also has radioprotective effect. Flavonoid quercetin in propolis potentiates the growth-inhibitory activity on tumors.(2)
It is very important to know that propolis composition varies geographically and depends on different factors. Therefore, the absence or decrease in key constituents with anti-tumor activities or decreased propolis dose may not be useful for the desired purpose.
The Brazilian Green Propolis is collected from the unexpanded leaf buds of Baccharis dracunculifolia plant by the Africanised honeybee. Only this bee specie has the capacity to produce Brazilian Green Propolis with concentrated Artepillin-C, a powerful constituent not found in propolis from other regions. Artepillin-C has strong anti-bacterial fighting properties and is well-known for its ability to suppress tumor growth (3)
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